What the FDA labels say about taking them together
Cimetidine and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates may be increased.”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the cimetidine label say about teriflunomide?
Cimetidine's label (effective July 15, 2026) does not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the teriflunomide label say about cimetidine?
Teriflunomide label, drug interactionsIn patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Teriflunomide | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Multiple sclerosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once