What the FDA labels say about taking them together
Cimetidine and oxymorphone
Oxymorphone's FDA label of June 29, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name oxymorphone. The oxymorphone label: “Cimetidine Clinical Impact Cimetidine can potentiate opioid-induced respiratory depression. Intervention Evaluate patients for respiratory depression when oxymorphone hydrochloride tablets and cimetidine are used …”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the oxymorphone FDA label on DailyMed (effective June 29, 2026, Aurolife Pharma, LLC).
What does the cimetidine label say about oxymorphone?
Cimetidine's label (effective July 15, 2026) does not name oxymorphone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the oxymorphone label say about cimetidine?
Oxymorphone label, drug interactionsCimetidine Clinical Impact Cimetidine can potentiate opioid-induced respiratory depression. Intervention Evaluate patients for respiratory depression when oxymorphone hydrochloride tablets and cimetidine are used concurrently. Serotonergic Drugs: Concomitant use may result in serotonin syndrome. Discontinue Oxymorphone Hydrochloride Tablets if serotonin syndrome is suspected. ( 7 ) Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics: Avoid use with oxymorphone hydrochloride tablets because they may reduce analgesic effect of oxymorphone hydrochloride tablets or precipitate withdrawal symptoms. ( 7 ) Monoamine oxidase inhibitors (MAOIs): Can potentiate the effects of oxymorphone. …
Source: FDA drug label (Oxymorphone Hydrochloride), Aurolife Pharma, LLC, effective June 29, 2026 (SPL set 22c7652a-aa16-4fa8-89d9-517e69059068), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Oxymorphone | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once