What the FDA labels say about taking them together
Cimetidine and naloxegol
Naloxegol's FDA label of September 1, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name naloxegol. The naloxegol label: “Weak CYP3A4 inhibitors •Clinically significant increases in naloxegol concentrations are not expected.”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.).
What does the cimetidine label say about naloxegol?
Cimetidine's label (effective July 15, 2026) does not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the naloxegol label say about cimetidine?
Naloxegol label, drug interactionsWeak CYP3A4 inhibitors (e.g., quinidine, cimetidine) •Clinically significant increases in naloxegol concentrations are not expected.
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Naloxegol | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $14.61 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once