What the FDA labels say about taking them together
Cilastatin/imipenem/relebactam and ganciclovir
Cilastatin/imipenem/relebactam's FDA label of December 9, 2025 names ganciclovir in its drug interactions section; the ganciclovir labels PlainMeds reads (2) do not name cilastatin/imipenem/relebactam. The cilastatin/imipenem/relebactam label: “DRUG INTERACTIONS Ganciclovir: Avoid concomitant use. Valproic Acid or Divalproex Sodium:”
Check it at the source: the cilastatin/imipenem/relebactam FDA label on DailyMed (effective December 9, 2025, Merck Sharp & Dohme LLC); the ganciclovir FDA label on DailyMed (effective January 9, 2026, Fresenius Kabi USA, LLC).
What does the cilastatin/imipenem/relebactam label say about ganciclovir?
Cilastatin/imipenem/relebactam label, drug interactionsDRUG INTERACTIONS Ganciclovir: Avoid concomitant use. ( 7.1 ) Valproic Acid or Divalproex Sodium:
Source: FDA drug label (RECARBRIO), Merck Sharp & Dohme LLC, effective December 9, 2025 (SPL set be32f468-738b-40df-a425-591e12f65159), via openFDA; the full label on DailyMed
What does the ganciclovir label say about cilastatin/imipenem/relebactam?
Ganciclovir's label (effective January 9, 2026) and its 1 other brand-application label do not name cilastatin/imipenem/relebactam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ganciclovir), Fresenius Kabi USA, LLC, effective January 9, 2026 (SPL set 35addab5-09db-4f8a-9c69-6fbce33ecc37), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cilastatin/imipenem/relebactam | Ganciclovir | |
|---|---|---|
| Labeled for | Urinary tract infections | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $91.24 per gram 0.15% ophthalmic gel |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once