What the FDA labels say about taking them together
Ciclesonide and ketoconazole
Ciclesonide's FDA label of February 28, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name ciclesonide. The ciclesonide label: “In a drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at …”
Check it at the source: the ciclesonide FDA label on DailyMed (effective February 28, 2025, Covis Pharma US, Inc); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the ciclesonide label say about ketoconazole?
Ciclesonide label, drug interactionsIn a drug interaction study, co-administration of orally inhaled ciclesonide and oral ketoconazole, a potent inhibitor of cytochrome P450 3A4, increased the exposure (AUC) of des-ciclesonide by approximately 3.6-fold at steady state, while levels of ciclesonide remained unchanged.
Source: FDA drug label (Alvesco), NDA021658 (Azurity), as published by Covis Pharma US, Inc, effective February 28, 2025 (SPL set 9f6112fb-78ef-43cf-8ae3-36370eb45468), via openFDA; the full label on DailyMed
What does the ketoconazole label say about ciclesonide?
Ketoconazole's label (effective January 28, 2026) does not name ciclesonide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciclesonide | Ketoconazole | |
|---|---|---|
| Labeled for | Asthma, Allergies | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $42.97 per gram 160 mcg inhaler | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once