What the FDA labels say about taking them together
Cholic acid and cyclosporine
Cholic acid's FDA label of January 26, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name cholic acid. The cholic acid label: “Bile Salt Efflux Pump (BSEP) Inhibitors (e.g., cyclosporine): Avoid concomitant use; if concomitant use is necessary, monitor serum transaminases and bilirubin”
Check it at the source: the cholic acid FDA label on DailyMed (effective January 26, 2026, Mirum Pharmaceuticals Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the cholic acid label say about cyclosporine?
Cholic acid label, drug interactionsBile Salt Efflux Pump (BSEP) Inhibitors (e.g., cyclosporine): Avoid concomitant use; if concomitant use is necessary, monitor serum transaminases and bilirubin
Source: FDA drug label (CHOLBAM), Mirum Pharmaceuticals Inc., effective January 26, 2026 (SPL set 5c6e4c9d-b85e-493f-9420-ab2fd0ff3723), via openFDA; the full label on DailyMed
What does the cyclosporine label say about cholic acid?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name cholic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cholic acid | Cyclosporine | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once