What the FDA labels say about taking them together
Cholic acid and colesevelam
Cholic acid's FDA label of January 26, 2026 names colesevelam in its drug interactions section; the colesevelam label PlainMeds reads does not name cholic acid. The cholic acid label: “Bile Acid Binding Resins Bile acid binding resins such as cholestyramine, colestipol, or colesevelam adsorb and reduce bile acid absorption and may reduce the efficacy of CHOLBAM.”
Check it at the source: the cholic acid FDA label on DailyMed (effective January 26, 2026, Mirum Pharmaceuticals Inc.); the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions).
What does the cholic acid label say about colesevelam?
Cholic acid label, drug interactionsBile Acid Binding Resins Bile acid binding resins such as cholestyramine, colestipol, or colesevelam adsorb and reduce bile acid absorption and may reduce the efficacy of CHOLBAM.
Source: FDA drug label (CHOLBAM), Mirum Pharmaceuticals Inc., effective January 26, 2026 (SPL set 5c6e4c9d-b85e-493f-9420-ab2fd0ff3723), via openFDA; the full label on DailyMed
What does the colesevelam label say about cholic acid?
Colesevelam's label (effective December 28, 2023) does not name cholic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cholic acid | Colesevelam | |
|---|---|---|
| Labeled for | n/a | High cholesterol, Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.262 per tablet 625 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once