What the FDA labels say about taking them together
Cholestyramine and hydrocortisone
Hydrocortisone's FDA label (Solu-Cortef) of August 27, 2026 names cholestyramine in its drug interactions section; the cholestyramine label PlainMeds reads does not name hydrocortisone. The hydrocortisone label: “Cholestyramine: Cholestyramine may increase the clearance of corticosteroids.”
Check it at the source: the cholestyramine FDA label on DailyMed (effective August 20, 2026, AiPing Pharmaceutical, Inc.); the hydrocortisone FDA label on DailyMed (effective August 19, 2026).
What does the cholestyramine label say about hydrocortisone?
Cholestyramine's label (effective August 20, 2026) does not name hydrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cholestyramine), AiPing Pharmaceutical, Inc., effective August 20, 2026 (SPL set 214ea05f-de81-4026-9df9-4ce3820668ee), via openFDA; the full label on DailyMed
What does the hydrocortisone label say about cholestyramine?
Solu-Cortef label (Pharmacia & Upjohn Company LLC, August 27, 2026), drug interactionsCholestyramine: Cholestyramine may increase the clearance of corticosteroids.
Source: FDA drug label (Solu-Cortef, NDA009866), Pharmacia & Upjohn Company LLC, effective August 27, 2026 (SPL set 65eefd58-b166-4d71-ade6-45c8fdf86922), via openFDA
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cholestyramine | Hydrocortisone | |
|---|---|---|
| Labeled for | High cholesterol | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.834 per packet Cholestyramine packet | $0.0613 per gram 1% cream |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once