What the FDA labels say about taking them together
Chlorthalidone and lithium
Chlorthalidone's FDA label (Thalitone) of June 25, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name chlorthalidone. The chlorthalidone label: “Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity.”
Check it at the source: the chlorthalidone FDA label on DailyMed (effective August 5, 2026, Macleods Pharmaceuticals Limited); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the chlorthalidone label say about lithium?
Thalitone label (Casper Pharma LLC, June 25, 2026), drug interactionsLithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity.
Source: FDA drug label (Thalitone, NDA019574), Casper Pharma LLC, effective June 25, 2026 (SPL set bc5a0299-115b-4e60-bb3f-c75a95c51c15), via openFDA
Source: FDA drug label (Chlorthalidone), Macleods Pharmaceuticals Limited, effective August 5, 2026 (SPL set 5de362df-8fb9-4421-864c-7ea06339d6e7), via openFDA; the full label on DailyMed
What does the lithium label say about chlorthalidone?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name chlorthalidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorthalidone | Lithium | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Edema (fluid retention) | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0743 per tablet 25 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once