What the FDA labels say about taking them together
Chlorpheniramine and epinephrine
Epinephrine's FDA label (Epipen) of February 15, 2023 names chlorpheniramine in its drug interactions section; the chlorpheniramine label PlainMeds reads does not name epinephrine.
Check it at the source: the chlorpheniramine FDA label on DailyMed (effective December 19, 2018, KVK-Tech, Inc.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the chlorpheniramine label say about epinephrine?
Chlorpheniramine's label (effective December 19, 2018) does not name epinephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Chlorphen-12), ANDA040829 (Avanthi Inc), as published by KVK-Tech, Inc., effective December 19, 2018 (SPL set 84409269-fe9b-469e-9a66-27b1475231a3), via openFDA; the full label on DailyMed
What does the epinephrine label say about chlorpheniramine?
Epipen label (Viatris Specialty LLC, February 15, 2023), drug interactionsAntidepressants, Monoamine Oxidase Inhibitors, Levothyroxine, and Antihistamines The effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine.
Source: FDA drug label (Epipen, NDA019430), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7560c201-9246-487c-a13b-6295db04274a), via openFDA
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorpheniramine | Epinephrine | |
|---|---|---|
| Labeled for | Allergies | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0177 per tablet 4 mg tablet | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once