What the FDA labels say about taking them together
Chlorothiazide and lithium
Chlorothiazide's FDA label of August 4, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name chlorothiazide.
Check it at the source: the chlorothiazide FDA label on DailyMed (effective August 4, 2026, Sagent Pharmaceuticals); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the chlorothiazide label say about lithium?
Chlorothiazide label, drug interactionsLithium - generally should not be given with diuretics.
Source: FDA drug label (chlorothiazide sodium), Sagent Pharmaceuticals, effective August 4, 2026 (SPL set 82dd0bdd-e6bd-48ea-8f58-c8bf71bbfe2c), via openFDA; the full label on DailyMed
What does the lithium label say about chlorothiazide?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name chlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorothiazide | Lithium | |
|---|---|---|
| Labeled for | Heart failure, Edema (fluid retention), High blood pressure | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.104 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once