What the FDA labels say about taking them together
Chlordiazepoxide/clidinium and diazepam
Chlordiazepoxide/clidinium's FDA label of January 13, 2023 names diazepam in its drug interactions section; diazepam's label does not name chlordiazepoxide/clidinium itself but warns about its class (Benzodiazepines). The chlordiazepoxide/clidinium label: “Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.”
Check it at the source: the chlordiazepoxide/clidinium FDA label on DailyMed (effective January 13, 2023, Bausch Health US, LLC); the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC).
What does the chlordiazepoxide/clidinium label say about diazepam?
Chlordiazepoxide/clidinium label, drug interactionsAlthough early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.
Source: FDA drug label (Librax), Bausch Health US, LLC, effective January 13, 2023 (SPL set f99ebf66-f207-4a97-9666-4da1d72b061c), via openFDA; the full label on DailyMed
What does the diazepam label say about chlordiazepoxide/clidinium?
Diazepam's label does not name chlordiazepoxide/clidinium itself; it warns about its class (Benzodiazepines):
Diazepam label, boxed warningABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS See full prescribing information for complete boxed warning Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. ( 5.1 , 7.1 ) The use of benzodiazepines, including VALTOCO, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.
Diazepam label, boxed warningABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlordiazepoxide/clidinium | Diazepam | |
|---|---|---|
| Labeled for | Irritable bowel syndrome | Anxiety, Muscle spasms and spasticity |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.256 per capsule Chlordiazepoxide-clidinium capsule | $0.0283 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once