What the FDA labels say about taking them together
Chlordiazepoxide and flumazenil
Chlordiazepoxide's FDA label of December 10, 2025 names flumazenil in its warnings section; flumazenil's label does not name chlordiazepoxide itself but warns about its class (Benzodiazepines). The chlordiazepoxide label: “Abrupt discontinuation or rapid dosage reduction of chlordiazepoxide after continued use, or administration of flumazenil may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) (see …”
Check it at the source: the chlordiazepoxide FDA label on DailyMed (effective December 10, 2025, Chartwell RX, LLC); the flumazenil FDA label on DailyMed (effective June 21, 2024, Hikma Pharmaceuticals USA Inc.).
What does the chlordiazepoxide label say about flumazenil?
Chlordiazepoxide label, warningsAbrupt discontinuation or rapid dosage reduction of chlordiazepoxide after continued use, or administration of flumazenil (a benzodiazepine antagonist) may precipitate acute withdrawal reactions, which can be life-threatening (e.g., seizures) (see DRUG ABUSE AND DEPENDENCE:
Source: FDA drug label (Chlordiazepoxide Hydrochloride), Chartwell RX, LLC, effective December 10, 2025 (SPL set dd5f82b0-5a56-4728-941a-c8c2a0d51cc4), via openFDA; the full label on DailyMed
What does the flumazenil label say about chlordiazepoxide?
Flumazenil's label does not name chlordiazepoxide itself; it warns about its class (Benzodiazepines):
Flumazenil label, contraindicationsCONTRAINDICATIONS Flumazenil is contraindicated: in patients with a known hypersensitivity to flumazenil or benzodiazepines. in patients who have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., control of intracranial pressure or status epilepticus). in patients who are showing signs of serious cyclic antidepressant overdose (see WARNINGS ).
Flumazenil label, boxed warningTHESE ARE MOST FREQUENT IN PATIENTS WHO HAVE BEEN ON BENZODIAZEPINES FOR LONG-TERM SEDATION OR IN OVERDOSE CASES WHERE PATIENTS ARE SHOWING SIGNS OF SERIOUS CYCLIC ANTIDEPRESSANT OVERDOSE.
Source: FDA drug label (Flumazenil), Hikma Pharmaceuticals USA Inc., effective June 21, 2024 (SPL set 436f5616-9626-4b6a-9deb-2986444179d0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlordiazepoxide | Flumazenil | |
|---|---|---|
| Labeled for | Anxiety, Alcohol use disorder | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.158 per capsule 25 mg capsule | $1.18 per mL 0.5 mg/5 mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once