What the FDA labels say about taking them together
Chlordiazepoxide and clorazepate
Clorazepate's FDA label of September 10, 2026 names chlordiazepoxide in its drug interactions section; chlordiazepoxide's label does not name clorazepate itself but warns about its class (Benzodiazepines). The clorazepate label: “Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.”
Check it at the source: the chlordiazepoxide FDA label on DailyMed (effective December 10, 2025, Chartwell RX, LLC); the clorazepate FDA label on DailyMed (effective September 10, 2026, Apotex Corp.).
What does the chlordiazepoxide label say about clorazepate?
Chlordiazepoxide's label does not name clorazepate itself; it warns about its class (Benzodiazepines):
Chlordiazepoxide label, boxed warningAND DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
Chlordiazepoxide label, boxed warningThe use of benzodiazepines, including chlordiazepoxide hydrochloride capsules, exposes users to risk of abuse, misuse, and addiction, which can lead to overdose or death.
Source: FDA drug label (Chlordiazepoxide Hydrochloride), Chartwell RX, LLC, effective December 10, 2025 (SPL set dd5f82b0-5a56-4728-941a-c8c2a0d51cc4), via openFDA; the full label on DailyMed
What does the clorazepate label say about chlordiazepoxide?
Clorazepate label, drug interactionsAlthough early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.
Source: FDA drug label (Clorazepate Dipotassium), ANDA215566 (Corepharma), as published by Apotex Corp., effective September 10, 2026 (SPL set 6e07efe5-29b6-6d1e-661a-f696c4b17f43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlordiazepoxide | Clorazepate | |
|---|---|---|
| Labeled for | Anxiety, Alcohol use disorder | Anxiety, Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.158 per capsule 25 mg capsule | $0.524 per tablet 3.75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once