What the FDA labels say about taking them together
Chlordiazepoxide and cimetidine
Cimetidine's FDA label of July 15, 2026 names chlordiazepoxide in its drug interactions section; the chlordiazepoxide label PlainMeds reads does not name cimetidine. The cimetidine label: “… metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and …”
Check it at the source: the chlordiazepoxide FDA label on DailyMed (effective December 10, 2025, Chartwell RX, LLC); the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.).
What does the chlordiazepoxide label say about cimetidine?
Chlordiazepoxide's label (effective December 10, 2025) does not name cimetidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Chlordiazepoxide Hydrochloride), Chartwell RX, LLC, effective December 10, 2025 (SPL set dd5f82b0-5a56-4728-941a-c8c2a0d51cc4), via openFDA; the full label on DailyMed
What does the cimetidine label say about chlordiazepoxide?
Cimetidine label, drug interactionsDrug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlordiazepoxide | Cimetidine | |
|---|---|---|
| Labeled for | Anxiety, Alcohol use disorder | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per capsule 25 mg capsule | $0.236 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once