What the FDA labels say about taking them together
Cetirizine and hydroxyzine
Cetirizine's FDA label of August 7, 2026 names hydroxyzine in its warnings section, and hydroxyzine's label names cetirizine too. The hydroxyzine label: “… hydroxyzine hydrochloride products, and in patients with known hypersensitivity to cetirizine hydrochloride or levocetirizine hydrochloride.”
Check it at the source: the cetirizine FDA label on DailyMed (effective August 7, 2026, GLENMARK THERAPEUTICS INC., USA); the hydroxyzine FDA label on DailyMed (effective March 3, 2026, Aurobindo Pharma Limited).
What does the cetirizine label say about hydroxyzine?
Cetirizine label, warningsWarnings Do not use if you have ever had an allergic reaction to this product or any of its ingredients or an antihistamine containing hydroxyzine Ask a doctor before useif you have liver or kidney disease.
Quzyttir label (TerSera Therapeutics LLC, March 4, 2026), contraindicationsCONTRAINDICATIONS The use of QUZYTTIR is contraindicated in patients with a known hypersensitivity to cetirizine hydrochloride or any of its ingredients, levocetirizine, or hydroxyzine.
Source: FDA drug label (Quzyttir, NDA211415), TerSera Therapeutics LLC, effective March 4, 2026 (SPL set f33e859d-ebc9-4d4f-a57d-204c48760d20), via openFDA
Source: FDA drug label (Cetirizine HCl), GLENMARK THERAPEUTICS INC., USA, effective August 7, 2026 (SPL set 04b08c52-5390-4cdb-a9e7-fca81fffdc73), via openFDA; the full label on DailyMed
What does the hydroxyzine label say about cetirizine?
Hydroxyzine label, contraindicationsCONTRAINDICATIONS Oral hydroxyzine hydrochloride is contraindicated in patients with known hypersensitivity to hydroxyzine hydrochloride products, and in patients with known hypersensitivity to cetirizine hydrochloride or levocetirizine hydrochloride.
Source: FDA drug label (Hydroxyzine Hydrochloride), Aurobindo Pharma Limited, effective March 3, 2026 (SPL set 9de2de56-614f-4294-8794-d30758cf5f70), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cetirizine | Hydroxyzine | |
|---|---|---|
| Labeled for | Allergies | Anxiety, Alcohol use disorder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0613 per tablet 10 mg tablet | $0.0326 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once