What the FDA labels say about taking them together
Cerliponase alfa and epinephrine
Cerliponase alfa's FDA label of August 5, 2024 names epinephrine in its boxed warning section; the epinephrine labels PlainMeds reads (4) do not name cerliponase alfa. The cerliponase alfa label: “… and immediately initiate appropriate medical treatment, including use of epinephrine.”
Check it at the source: the cerliponase alfa FDA label on DailyMed (effective August 5, 2024, BioMarin Pharmaceutical Inc.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the cerliponase alfa label say about epinephrine?
Cerliponase alfa label, boxed warningHYPERSENSITIVITY REACTIONS INCLUDING ANAPHYLAXIS See full prescribing information for complete boxed warning Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy. ( 5.1 ) Initiate BRINEURA in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. ( 5.1 ) If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue BRINEURA and immediately initiate appropriate medical treatment, including use of epinephrine.
Cerliponase alfa label, warnings and precautionsEpinephrine was administered in these patients, and they received subsequent BRINEURA infusions without recurrence of anaphylaxis.
Source: FDA drug label (Brineura), BioMarin Pharmaceutical Inc., effective August 5, 2024 (SPL set 485ab3c5-0359-4878-872f-2fe1e7df4047), via openFDA; the full label on DailyMed
What does the epinephrine label say about cerliponase alfa?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name cerliponase alfa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cerliponase alfa | Epinephrine | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once