What the FDA labels say about taking them together
Ceritinib and rifampin
Ceritinib's FDA label of December 15, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name ceritinib. The ceritinib label: “Strong CYP3A Inducers A strong CYP3A4/P-gp inducer (rifampin) decreased the systemic exposure of ceritinib, which may decrease the efficacy of ZYKADIA.”
Check it at the source: the ceritinib FDA label on DailyMed (effective December 15, 2025, Novartis Pharmaceuticals Corporation); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the ceritinib label say about rifampin?
Ceritinib label, drug interactionsStrong CYP3A Inducers A strong CYP3A4/P-gp inducer (rifampin) decreased the systemic exposure of ceritinib [see Clinical Pharmacology (12.3)], which may decrease the efficacy of ZYKADIA.
Source: FDA drug label (ZYKADIA), Novartis Pharmaceuticals Corporation, effective December 15, 2025 (SPL set fff5d805-4ffd-4e8e-8e63-6f129697563e), via openFDA; the full label on DailyMed
What does the rifampin label say about ceritinib?
Rifampin's label (effective February 11, 2026) does not name ceritinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ceritinib | Rifampin | |
|---|---|---|
| Labeled for | Lung cancer | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once