What the FDA labels say about taking them together
Ceritinib and ketoconazole
Ceritinib's FDA label of December 15, 2025 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name ceritinib. The ceritinib label: “Drugs on ZYKADIA Strong CYP3A Inhibitors A strong CYP3A4/P-gp inhibitor (ketoconazole) increased the systemic exposure of ceritinib, which may increase the incidence and severity of adverse reactions of ZYKADIA.”
Check it at the source: the ceritinib FDA label on DailyMed (effective December 15, 2025, Novartis Pharmaceuticals Corporation); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the ceritinib label say about ketoconazole?
Ceritinib label, drug interactionsDrugs on ZYKADIA Strong CYP3A Inhibitors A strong CYP3A4/P-gp inhibitor (ketoconazole) increased the systemic exposure of ceritinib [see Clinical Pharmacology (12.3)], which may increase the incidence and severity of adverse reactions of ZYKADIA.
Source: FDA drug label (ZYKADIA), Novartis Pharmaceuticals Corporation, effective December 15, 2025 (SPL set fff5d805-4ffd-4e8e-8e63-6f129697563e), via openFDA; the full label on DailyMed
What does the ketoconazole label say about ceritinib?
Ketoconazole's label (effective January 28, 2026) does not name ceritinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ceritinib | Ketoconazole | |
|---|---|---|
| Labeled for | Lung cancer | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once