What the FDA labels say about taking them together
Celecoxib and diclofenac
Celecoxib's FDA label of November 22, 2024 names diclofenac in its drug interactions section; diclofenac's label does not name celecoxib itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)).
Check it at the source: the celecoxib FDA label on DailyMed (effective November 22, 2024, Viatris Specialty LLC); the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC).
What does the celecoxib label say about diclofenac?
Celecoxib label, drug interactionsNSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Celecoxib label, warnings and precautionsIn the CLASS study [see Clinical Studies (14.7) ], the Kaplan-Meier cumulative rates at 9 months of peripheral edema in patients on CELEBREX 400 mg twice daily (4-fold and 2-fold the recommended OA and RA doses, respectively), ibuprofen 800 mg three times daily and diclofenac 75 mg twice daily were 4.5%, 6.9% and 4.7%, respectively.
Elyxyb - Celecoxib label (SCILEX PHARMACEUTICALS INC., November 26, 2024), warnings and precautionsIn a clinical study, the cumulative rates at 9 months of peripheral edema in patients on celecoxib capsules 400 mg twice daily, ibuprofen 800 mg three times daily, and diclofenac 75 mg twice daily were 4.5%, 6.9%, and 4.7%, respectively.
Source: FDA drug label (Vyscoxa, NDA211759), Carwin Pharmaceutical Associates, LLC, effective July 31, 2025 (SPL set 5094d47e-f791-4190-9397-b7500143a74d), via openFDA
Source: FDA drug label (Elyxyb - Celecoxib, NDA212157), SCILEX PHARMACEUTICALS INC., effective November 26, 2024 (SPL set c8a5de07-9f27-4a54-a885-8089f0307bd7), via openFDA
Source: FDA drug label (CELEBREX), NDA020998 (Upjohn), as published by Viatris Specialty LLC, effective November 22, 2024 (SPL set 2d6675e4-5859-4be2-8037-a20ce9f707aa), via openFDA; the full label on DailyMed
What does the diclofenac label say about celecoxib?
Diclofenac's label does not name celecoxib itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Diclofenac label, boxed warningThis risk may occur early in the treatment and may increase with duration of use ( 5.1 ) LICART is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. ( 4 , 5.1 ) NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Diclofenac label, boxed warningGastrointestinal Bleeding, Ulceration, and Perforation NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Celecoxib | Diclofenac | |
|---|---|---|
| Labeled for | Osteoarthritis, Rheumatoid arthritis, Pain, Migraine | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0762 per capsule 200 mg capsule | $0.0619 per tablet 75 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once