Celecoxib and Diclofenac Interaction
Drug interaction information between Celecoxib and Diclofenac.
Celecoxib and Diclofenac have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Celecoxib and Diclofenac. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking two different NSAID pain relievers at the same time increases the chance of serious side effects like stomach ulcers or kidney issues.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Digoxin minor
- Fluconazole minor
- Indomethacin minor
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Diclofenac?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Celecoxib has 19 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Celecoxib has 16 (also Meloxicam, Furosemide, Aspirin, Propranolol); Diclofenac has 9 (also Digoxin, Fluconazole, Indomethacin, Mefenamic Acid).
What mechanism field is on file for Celecoxib and Diclofenac?
Taking two different NSAID pain relievers at the same time increases the chance of serious side effects like stomach ulcers or kidney issues.
Celecoxib's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Celecoxib (COX-2 Selective NSAID); Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Digoxin
- Fluconazole
- Indomethacin
- Mefenamic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.