What the FDA labels say about taking them together
Ceftriaxone and lidocaine
Ceftriaxone's FDA label of February 4, 2026 names lidocaine in its contraindications section; the lidocaine labels PlainMeds reads (4) do not name ceftriaxone. The ceftriaxone label: “Lidocaine Intravenous administration of ceftriaxone solutions containing lidocaine is contraindicated.”
Check it at the source: the ceftriaxone FDA label on DailyMed (effective February 4, 2026, Qilu Pharmaceutical Co., Ltd.); the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC).
What does the ceftriaxone label say about lidocaine?
Ceftriaxone label, contraindicationsLidocaine Intravenous administration of ceftriaxone solutions containing lidocaine is contraindicated.
Source: FDA drug label (Ceftriaxone Sodium), Qilu Pharmaceutical Co., Ltd., effective February 4, 2026 (SPL set 4cdf0743-c62b-4969-b9c9-4c6400644f6c), via openFDA; the full label on DailyMed
What does the lidocaine label say about ceftriaxone?
Lidocaine's label (effective May 13, 2024) and its 3 other brand-application labels do not name ceftriaxone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ceftriaxone | Lidocaine | |
|---|---|---|
| Labeled for | Urinary tract infections, Bacterial infections | Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.44 per vial 1 g vial | $0.154 per gram 5% ointment |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once