What the FDA labels say about taking them together
Cefpodoxime and sodium bicarbonate
Cefpodoxime's FDA label of July 30, 2026 names sodium bicarbonate in its drug interactions section; the sodium bicarbonate labels PlainMeds reads (3) do not name cefpodoxime. The cefpodoxime label: “Drug Interactions Antacids Concomitant administration of high doses of antacids or H 2 blockers reduces peak plasma levels by 24% to 42% and the extent of absorption by 27% to 32%, respectively.”
Check it at the source: the cefpodoxime FDA label on DailyMed (effective July 30, 2026, Sandoz Inc); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the cefpodoxime label say about sodium bicarbonate?
Cefpodoxime label, drug interactionsDrug Interactions Antacids Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H 2 blockers reduces peak plasma levels by 24% to 42% and the extent of absorption by 27% to 32%, respectively.
Source: FDA drug label (Cefpodoxime Proxetil), Sandoz Inc, effective July 30, 2026 (SPL set 8519a9d8-7106-4545-bc58-859ee9a6708e), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about cefpodoxime?
Sodium bicarbonate's label (effective August 4, 2026) and its 2 other brand-application labels do not name cefpodoxime in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cefpodoxime | Sodium bicarbonate | |
|---|---|---|
| Labeled for | Bacterial infections | Acid reflux and ulcers, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.04 per tablet 100 mg tablet | $0.154 per mL 8.4% vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once