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What the FDA labels say about taking them together

Cefaclor and teriflunomide

Teriflunomide's FDA label of February 20, 2026 names cefaclor in its drug interactions section; the cefaclor label PlainMeds reads does not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates may be increased.”

Check it at the source: the cefaclor FDA label on DailyMed (effective November 1, 2022, Azorian Pharma, LLC); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).

What does the cefaclor label say about teriflunomide?

Cefaclor's label (effective November 1, 2022) does not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Cefaclor), Azorian Pharma, LLC, effective November 1, 2022 (SPL set 224af904-38f3-4210-a750-e21006db4c66), via openFDA; the full label on DailyMed

What does the teriflunomide label say about cefaclor?

Teriflunomide label, drug interactions

In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.

Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Cefaclor generic labelers
15Teriflunomide generic labelers
CefaclorTeriflunomide
Labeled forn/aMultiple sclerosis
Boxed warningNoYes
Pharmacy cost (NADAC)$0.932 per capsule 250 mg capsule$0.233 per tablet 14 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?