What the FDA labels say about taking them together
Castor oil and tacrolimus
Tacrolimus's FDA label of July 17, 2026 names castor oil in its contraindications section; the castor oil label PlainMeds reads does not name tacrolimus. The tacrolimus label: “PROGRAF injection is contraindicated in patients with a hypersensitivity to HCO-60.”
Check it at the source: the castor oil FDA label on DailyMed (effective June 15, 2026); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the castor oil label say about tacrolimus?
Castor oil's label (effective June 15, 2026) does not name tacrolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Signature Care), Better Living Brands, LLC, effective June 15, 2026 (SPL set 4947cf4d-3ebd-4b66-9582-f141407aa300), via openFDA; the full label on DailyMed
What does the tacrolimus label say about castor oil?
Tacrolimus label, contraindicationsCONTRAINDICATIONS Hypersensitivity to tacrolimus or HCO-60 (polyoxyl 60 hydrogenated castor oil). ( 4 ) Tacrolimus capsules are contraindicated in patients with a hypersensitivity to tacrolimus.
Prograf label (Astellas Pharma US, Inc., August 25, 2023), contraindicationsPROGRAF injection is contraindicated in patients with a hypersensitivity to HCO-60 (polyoxyl 60 hydrogenated castor oil).
Source: FDA drug label (Prograf, NDA050708), Astellas Pharma US, Inc., effective August 25, 2023 (SPL set 7f667de1-9dfa-4bd6-8ba0-15ee2d78873b), via openFDA
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Castor oil | Tacrolimus | |
|---|---|---|
| Labeled for | Constipation | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0193 per mL Castor oil | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once