What the FDA labels say about taking them together
Carvedilol and propafenone
Carvedilol's FDA label of July 31, 2026 names propafenone in its drug interactions section; propafenone's label does not name carvedilol itself but warns about its class (Beta blockers). The carvedilol label: “Inhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of …”
Check it at the source: the carvedilol FDA label on DailyMed (effective July 31, 2026, Waylis Therapeutics LLC); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the carvedilol label say about propafenone?
Carvedilol label, drug interactionsInhibitors and Poor Metabolizers Interactions of carvedilol with potent inhibitors of CYP2D6 isoenzyme (such as quinidine, fluoxetine, paroxetine, and propafenone) have not been studied, but these drugs would be expected to increase blood levels of the R(+) enantiomer of carvedilol [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Coreg), Waylis Therapeutics LLC, effective July 31, 2026 (SPL set 07c619c6-4a0c-445e-94fa-664a54f68a39), via openFDA; the full label on DailyMed
What does the propafenone label say about carvedilol?
Propafenone's label does not name carvedilol itself; it warns about its class (Beta blockers):
Propafenone label, drug interactionsIn clinical trials using propafenone immediate release tablets, subjects who were receiving beta-blockers concurrently did not experience an increased incidence of side effects.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carvedilol | Propafenone | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0179 per tablet 6.25 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once