What the FDA labels say about taking them together
Carfilzomib and prednisone
Carfilzomib's FDA label of June 18, 2025 names prednisone in its warnings and precautions section; the prednisone label PlainMeds reads does not name carfilzomib. The carfilzomib label: “Discontinue Kyprolis in patients who develop PML. Increased Fatal and Serious Toxicities in Combination with Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Patients Embryo-Fetal Toxicity:”
Check it at the source: the carfilzomib FDA label on DailyMed (effective June 18, 2025, Onyx Pharmaceuticals, Inc.); the prednisone FDA label on DailyMed (effective April 22, 2025, Hikma Pharmaceuticals USA Inc.).
What does the carfilzomib label say about prednisone?
Carfilzomib label, warnings and precautionsDiscontinue Kyprolis in patients who develop PML. ( 5.15 ) Increased Fatal and Serious Toxicities in Combination with Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Patients ( 5.16 ) Embryo-Fetal Toxicity:
Source: FDA drug label (KYPROLIS), Onyx Pharmaceuticals, Inc., effective June 18, 2025 (SPL set ea66eb30-e665-4693-99a1-a9d3b4bbe2d6), via openFDA; the full label on DailyMed
What does the prednisone label say about carfilzomib?
Prednisone's label (effective April 22, 2025) does not name carfilzomib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PredniSONE), Hikma Pharmaceuticals USA Inc., effective April 22, 2025 (SPL set 3115aef0-fd50-4ec8-a064-3effb695f3f2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carfilzomib | Prednisone | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Eczema (atopic dermatitis), Anemia, Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0643 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once