What the FDA labels say about taking them together
Carfilzomib and melphalan
Carfilzomib's FDA label of June 18, 2025 names melphalan in its warnings and precautions section; the melphalan labels PlainMeds reads (4) do not name carfilzomib. The carfilzomib label: “Discontinue Kyprolis in patients who develop PML. Increased Fatal and Serious Toxicities in Combination with Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Patients Embryo-Fetal Toxicity:”
Check it at the source: the carfilzomib FDA label on DailyMed (effective June 18, 2025, Onyx Pharmaceuticals, Inc.); the melphalan FDA label on DailyMed (effective July 7, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the carfilzomib label say about melphalan?
Carfilzomib label, warnings and precautionsDiscontinue Kyprolis in patients who develop PML. ( 5.15 ) Increased Fatal and Serious Toxicities in Combination with Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Patients ( 5.16 ) Embryo-Fetal Toxicity:
Source: FDA drug label (KYPROLIS), Onyx Pharmaceuticals, Inc., effective June 18, 2025 (SPL set ea66eb30-e665-4693-99a1-a9d3b4bbe2d6), via openFDA; the full label on DailyMed
What does the melphalan label say about carfilzomib?
Melphalan's label (effective July 7, 2026) and its 3 other brand-application labels do not name carfilzomib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Melphalan hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective July 7, 2026 (SPL set 2c18beeb-7bd4-4591-94cb-9d7156c1b8e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carfilzomib | Melphalan | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once