What the FDA labels say about taking them together
Carfilzomib and dexamethasone
Carfilzomib's FDA label of June 18, 2025 names dexamethasone in its warnings and precautions section, and dexamethasone's label names carfilzomib too. The dexamethasone label: “The risk for venous and arterial thromboembolism increases significantly when dexamethasone is administered with anti-myeloma products.”
Check it at the source: the carfilzomib FDA label on DailyMed (effective June 18, 2025, Onyx Pharmaceuticals, Inc.); the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.).
What does the carfilzomib label say about dexamethasone?
Carfilzomib label, warnings and precautionsThromboprophylaxis is recommended. ( 5.8 ) Infusion-related Reactions: Premedicate with dexamethasone.
Source: FDA drug label (KYPROLIS), Onyx Pharmaceuticals, Inc., effective June 18, 2025 (SPL set ea66eb30-e665-4693-99a1-a9d3b4bbe2d6), via openFDA; the full label on DailyMed
What does the dexamethasone label say about carfilzomib?
Hemady label (Edenbridge Pharmaceuticals LLC., January 9, 2026), warnings and precautionsThe risk for venous and arterial thromboembolism increases significantly when dexamethasone is administered with anti-myeloma products (e.g., thalidomide, lenalidomide, pomalidomide, and carfilzomib).
Source: FDA drug label (Hemady, NDA211379), Edenbridge Pharmaceuticals LLC., effective January 9, 2026 (SPL set 6b9cf32c-6d60-4853-bbfd-2304ffc2c129), via openFDA
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carfilzomib | Dexamethasone | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.193 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once