What the FDA labels say about taking them together

Carboplatin and sorafenib

Sorafenib's FDA label of August 28, 2023 names carboplatin in its contraindications section; the carboplatin labels PlainMeds reads (2) do not name sorafenib. The sorafenib label: “NEXAVAR in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer.”

Check it at the source: the carboplatin FDA label on DailyMed (effective January 10, 2025, Eugia US LLC); the sorafenib FDA label on DailyMed (effective August 28, 2023, Bayer HealthCare Pharmaceuticals Inc.).

What does the carboplatin label say about sorafenib?

Carboplatin's label (effective January 10, 2025) and its 1 other brand-application label do not name sorafenib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (CARBOPLATIN), Eugia US LLC, effective January 10, 2025 (SPL set f5fe9a20-47a5-45b9-ab06-c6158d9b6aca), via openFDA; the full label on DailyMed

What does the sorafenib label say about carboplatin?

Sorafenib label, contraindications
NEXAVAR in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer [see Warnings and Precautions ( 5.8 )].

Sorafenib label, warnings and precautions
Observed with NEXAVAR Administered in Combination with Carboplatin/Paclitaxel and Gemcitabine/Cisplatin in Squamous Cell Lung Cancer In a subset analysis of two randomized controlled trials in chemo-naive patients with Stage IIIB-IV non-small cell lung cancer, patients with squamous cell carcinoma experienced higher mortality with the addition of NEXAVAR compared to those treated with carboplatin/paclitaxel alone (HR 1.81;

Source: FDA drug label (Nexavar), Bayer HealthCare Pharmaceuticals Inc., effective August 28, 2023 (SPL set b50667e4-5ebc-4968-a646-d605058dbef0), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

10Carboplatin generic labelers

7Sorafenib generic labelers

	Carboplatin	Sorafenib
Labeled for	n/a	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	n/a	n/a
Shortage now	In shortage	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Carboplatin: the full record
Sorafenib: the full record
Check more medicines together: up to five at once