What the FDA labels say about taking them together
Carboplatin and cisplatin
Carboplatin's FDA label of January 10, 2025 names cisplatin in its contraindications section, and cisplatin's label names carboplatin too. The carboplatin label: “CONTRAINDICATIONS Carboplatin injection is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds, or mannitol.”
Check it at the source: the carboplatin FDA label on DailyMed (effective January 10, 2025, Eugia US LLC); the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC).
What does the carboplatin label say about cisplatin?
Carboplatin label, contraindicationsCONTRAINDICATIONS Carboplatin injection is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds, or mannitol.
Carboplatin label, warningsBone marrow suppression is increased in patients who have received prior therapy, especially regimens including cisplatin.
Source: FDA drug label (CARBOPLATIN), Eugia US LLC, effective January 10, 2025 (SPL set f5fe9a20-47a5-45b9-ab06-c6158d9b6aca), via openFDA; the full label on DailyMed
What does the cisplatin label say about carboplatin?
Cisplatin label, boxed warningCare must be taken to avoid inadvertent cisplatin overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle.
Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carboplatin | Cisplatin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once