What the FDA labels say about taking them together
Carbidopa/levodopa and tetrabenazine
Carbidopa/levodopa's FDA label of August 1, 2026 names tetrabenazine in its drug interactions section; the tetrabenazine label PlainMeds reads does not name carbidopa/levodopa. The carbidopa/levodopa label: “Use of DHIVY with dopamine-depleting agents or other drugs known to deplete monoamine stores is not recommended.”
Check it at the source: the carbidopa/levodopa FDA label on DailyMed (effective August 1, 2026, Organon LLC); the tetrabenazine FDA label on DailyMed (effective November 29, 2019, Oceanside Pharmaceuticals).
What does the carbidopa/levodopa label say about tetrabenazine?
Carbidopa/levodopa label, drug interactionsUse of SINEMET with dopamine-depleting agents (e.g., reserpine and tetrabenazine) or other drugs known to deplete monoamine stores is not recommended.
Source: FDA drug label (Dhivy, NDA214869), Avion Pharmaceuticals, LLC, effective August 21, 2026 (SPL set 39d79ade-8ee0-40ba-9fdd-13045b8ddbdf), via openFDA
Source: FDA drug label (SINEMET), Organon LLC, effective August 1, 2026 (SPL set 9b17b028-964a-473c-823d-81423535bd66), via openFDA; the full label on DailyMed
What does the tetrabenazine label say about carbidopa/levodopa?
Tetrabenazine's label (effective November 29, 2019) does not name carbidopa/levodopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (tetrabenazine), NDA021894 (Bausch), as published by Oceanside Pharmaceuticals, effective November 29, 2019 (SPL set 5867189c-17bd-4e70-a079-c4730f9950d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbidopa/levodopa | Tetrabenazine | |
|---|---|---|
| Labeled for | Parkinson's disease | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0759 per tablet 25-100 tablet | $0.702 per tablet 12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once