What the FDA labels say about taking them together
Carbidopa and selegiline
Carbidopa's FDA label of July 2, 2020 names selegiline in its contraindications section; the selegiline labels PlainMeds reads (3) do not name carbidopa. The carbidopa label: “Carbidopa-levodopa, or levodopa may be administered concomitantly with the manufacturer’s recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g., selegiline HCl).”
Check it at the source: the carbidopa FDA label on DailyMed (effective July 2, 2020, Oceanside Pharmaceuticals); the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.).
What does the carbidopa label say about selegiline?
Carbidopa label, contraindicationsCarbidopa-levodopa, or levodopa may be administered concomitantly with the manufacturer’s recommended dose of an MAO inhibitor with selectivity for MAO type B (e.g., selegiline HCl) (see PRECAUTIONS, Drug Interactions ).
Carbidopa label, drug interactionsConcomitant therapy with selegiline or rasigiline and carbidopa or carbidopa-levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa-levodopa alone (see CONTRAINDICATIONS ).
Source: FDA drug label (Carbidopa), NDA017830 (Aton), as published by Oceanside Pharmaceuticals, effective July 2, 2020 (SPL set d5204e5e-10ef-4758-8fc6-cb710048c687), via openFDA; the full label on DailyMed
What does the selegiline label say about carbidopa?
Selegiline's label (effective August 7, 2024) and its 2 other brand-application labels do not name carbidopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbidopa | Selegiline | |
|---|---|---|
| Labeled for | Parkinson's disease | Parkinson's disease, Depression |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.536 per tablet 25 mg tablet | $0.756 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once