What the FDA labels say about taking them together
Carbidopa and metoclopramide
Carbidopa's FDA label of July 2, 2020 names metoclopramide in its drug interactions section; the metoclopramide labels PlainMeds reads (2) do not name carbidopa. The carbidopa label: “Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.”
Check it at the source: the carbidopa FDA label on DailyMed (effective July 2, 2020, Oceanside Pharmaceuticals); the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.).
What does the carbidopa label say about metoclopramide?
Carbidopa label, drug interactionsAlthough metoclopramide may increase the bioavailability of levodopa by increasing gastric emptying, metoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.
Source: FDA drug label (Carbidopa), NDA017830 (Aton), as published by Oceanside Pharmaceuticals, effective July 2, 2020 (SPL set d5204e5e-10ef-4758-8fc6-cb710048c687), via openFDA; the full label on DailyMed
What does the metoclopramide label say about carbidopa?
Metoclopramide's label (effective May 18, 2026) and its 1 other brand-application label do not name carbidopa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Carbidopa | Metoclopramide | |
|---|---|---|
| Labeled for | Parkinson's disease | Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.536 per tablet 25 mg tablet | $0.0439 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once