What the FDA labels say about taking them together
Captopril/hydrochlorothiazide and diazoxide
Captopril/hydrochlorothiazide's FDA label of February 21, 2023 names diazoxide in its drug interactions section; diazoxide's label does not name captopril/hydrochlorothiazide itself but warns about its class (ACE inhibitors, Thiazide diuretics).
Check it at the source: the captopril/hydrochlorothiazide FDA label on DailyMed (effective February 21, 2023, Rising Pharma Holdings, Inc.); the diazoxide FDA label on DailyMed (effective March 26, 2025, Soleno Therapeutics, Inc.).
What does the captopril/hydrochlorothiazide label say about diazoxide?
Captopril/hydrochlorothiazide label, drug interactionsDiazoxide: enhanced hyperglycemic, hyperuricemic, and antihypertensive effects.
Source: FDA drug label (CAPTOPRIL AND HYDROCHLOROTHIAZIDE), Rising Pharma Holdings, Inc., effective February 21, 2023 (SPL set 0ea90fd4-0da6-4ad2-ab83-6cfbe0ae515e), via openFDA; the full label on DailyMed
What does the diazoxide label say about captopril/hydrochlorothiazide?
Diazoxide's label does not name captopril/hydrochlorothiazide itself; it warns about its class (ACE inhibitors, Thiazide diuretics):
Diazoxide label, contraindicationsCONTRAINDICATIONS VYKAT XR is contraindicated in patients with known hypersensitivity to diazoxide, other components of VYKAT XR, or to thiazides.
Diazoxide label, contraindicationsFunctional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides
Source: FDA drug label (VYKAT XR), Soleno Therapeutics, Inc., effective March 26, 2025 (SPL set 0e745e85-9512-e360-e063-6394a90aebf1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril/hydrochlorothiazide | Diazoxide | |
|---|---|---|
| Labeled for | High blood pressure | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $7.38 per mL 50 mg/mL oral suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once