What the FDA labels say about taking them together
Captopril and sacubitril/valsartan
Captopril's FDA label of February 6, 2026 names sacubitril/valsartan in its contraindications section; sacubitril/valsartan's label does not name captopril itself but warns about its class (ACE inhibitors). The captopril label: “Do not administer captopril tablets within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor.”
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the sacubitril/valsartan FDA label on DailyMed (effective July 6, 2026, Novartis Pharmaceuticals Corporation).
What does the captopril label say about sacubitril/valsartan?
Captopril label, contraindicationsDo not administer captopril tablets within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see PRECAUTIONS, Drug Interactions ).
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the sacubitril/valsartan label say about captopril?
Sacubitril/valsartan's label does not name captopril itself; it warns about its class (ACE inhibitors):
Sacubitril/valsartan label, contraindicationsCONTRAINDICATIONS ENTRESTO is contraindicated: in patients with hypersensitivity to any component in patients with a history of angioedema related to previous ACE inhibitor or ARB therapy [see Warnings and Precautions (5.2)] with concomitant use of ACE inhibitors.
Sacubitril/valsartan label, drug interactionsBlockade of the Renin-Angiotensin-Aldosterone System Concomitant use of ENTRESTO with an ACE inhibitor is contraindicated because of the increased risk of angioedema [see Contraindications (4)].
Source: FDA drug label (ENTRESTO), Novartis Pharmaceuticals Corporation, effective July 6, 2026 (SPL set 000dc81d-ab91-450c-8eae-8eb74e72296f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Sacubitril/valsartan | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | Heart failure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $0.533 per unit 49-51 mg |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once