What the FDA labels say about taking them together
Captopril and nitroglycerin
Captopril's FDA label of February 6, 2026 names nitroglycerin in its drug interactions section; the nitroglycerin labels PlainMeds reads (4) do not name captopril.
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the captopril label say about nitroglycerin?
Captopril label, drug interactionsAgents Having Vasodilator Activity: Data on the effect of concomitant use of other vasodilators in patients receiving captopril tablets for heart failure are not available; therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril tablets.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about captopril?
Nitroglycerin's label (effective February 15, 2023) and its 3 other brand-application labels do not name captopril in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Nitroglycerin | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once