What the FDA labels say about taking them together
Captopril and naldemedine
Naldemedine's FDA label of July 25, 2025 names captopril in its drug interactions section; the captopril label PlainMeds reads does not name naldemedine. The naldemedine label: “P-glycoprotein (P-gp) Inhibitors Clinical Impact Increase in plasma naldemedine concentrations Intervention Monitor for potential naldemedine-related adverse reactions. …”
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the naldemedine FDA label on DailyMed (effective July 25, 2025, BioDelivery Sciences International Inc).
What does the captopril label say about naldemedine?
Captopril's label (effective February 6, 2026) does not name naldemedine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the naldemedine label say about captopril?
Naldemedine label, drug interactionsP-glycoprotein (P-gp) Inhibitors (e.g., amiodarone, captopril, cyclosporine, quercetin, quinidine, verapamil) Clinical Impact Increase in plasma naldemedine concentrations [see Clinical Pharmacology (12.3) ] Intervention Monitor for potential naldemedine-related adverse reactions [see Adverse Reactions (6.1) ]. Strong CYP3A inducers (e.g., rifampin): Decreased naldemedine concentrations; avoid concomitant use ( 7 ) Other opioid antagonists: Potential for additive effect and increased risk of opioid withdrawal; avoid concomitant use ( 7 ) Moderate (e.g., fluconazole) and strong (e.g., itraconazole) CYP3A4 inhibitors: Increased naldemedine concentrations; …
Source: FDA drug label (SYMPROIC), NDA208854 (Bdsi), as published by BioDelivery Sciences International Inc, effective July 25, 2025 (SPL set b1a1256c-a1eb-4abe-ab1e-30e4711afd16), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Naldemedine | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $16.26 per tablet 0.2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once