What the FDA labels say about taking them together
Captopril and indomethacin
Indomethacin's FDA label (Indomethacin) of March 26, 2025 names captopril in its drug interactions section; captopril's label does not name indomethacin itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The indomethacin label: “Indomethacin can reduce the antihypertensive effects of captopril and losartan.”
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the captopril label say about indomethacin?
Captopril's label does not name indomethacin itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Captopril label, drug interactionsAvoid use of aliskiren with captopril tablets in patients with renal impairment (GFR <60 ml/min). Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase – 2 Inhibitors (COX-2 Inhibitors):
Captopril label, drug interactionsMonitor renal function periodically in patients receiving captopril and NSAID therapy.
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the indomethacin label say about captopril?
Indomethacin label (Chartwell RX, LLC, March 26, 2025), drug interactionsIndomethacin can reduce the antihypertensive effects of captopril and losartan.
Source: FDA drug label (Indomethacin, NDA018829), Chartwell RX, LLC, effective March 26, 2025 (SPL set 9607920c-4d25-40b9-957e-87e9ca5574e8), via openFDA
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Indomethacin | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once