What the FDA labels say about taking them together
Captopril and everolimus
Captopril's FDA label of February 6, 2026 names everolimus in its warnings section; everolimus's label does not name captopril itself but warns about its class (ACE inhibitors). The captopril label: “Information for Patients and ADVERSE REACTIONS.) Patients receiving coadministration of ACE inhibitor and mTOR inhibitor therapy or a neprilysin inhibitor may be at increased risk for angioedema.”
Check it at the source: the captopril FDA label on DailyMed (effective February 6, 2026, AiPing Pharmaceutical, Inc.); the everolimus FDA label on DailyMed (effective June 1, 2026, Novartis Pharmaceuticals Corporation).
What does the captopril label say about everolimus?
Captopril label, warningsInformation for Patients and ADVERSE REACTIONS .) Patients receiving coadministration of ACE inhibitor and mTOR (mammalian target of rapamycin) inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema (see PRECAUTIONS, Drug Interactions ).
Source: FDA drug label (Captopril), AiPing Pharmaceutical, Inc., effective February 6, 2026 (SPL set 3b789f16-b291-4012-be39-af3beec3ff9a), via openFDA; the full label on DailyMed
What does the everolimus label say about captopril?
Everolimus's label does not name captopril itself; it warns about its class (ACE inhibitors):
Everolimus label, drug interactionsUse of Angiotensin Converting Enzyme (ACE) Inhibitors Patients taking concomitant ACE inhibitors with AFINITOR/AFINITOR DISPERZ may be at increased risk for angioedema.
Everolimus label, drug interactionsAvoid the concomitant use of ACE inhibitors with AFINITOR/AFINITOR DISPERZ [see Warnings and Precautions (5.4)].
Source: FDA drug label (Afinitor), Novartis Pharmaceuticals Corporation, effective June 1, 2026 (SPL set 2150f73a-179b-4afc-b8ce-67c85cc72f04), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Captopril | Everolimus | |
|---|---|---|
| Labeled for | High blood pressure, Heart failure, Chronic kidney disease | Breast cancer, Seizures and epilepsy, Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.228 per tablet 12.5 mg tablet | $26.32 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once