What the FDA labels say about taking them together
Caplacizumab and heparin
Caplacizumab's FDA label of April 24, 2026 names heparin in its drug interactions section; the heparin labels PlainMeds reads (4) do not name caplacizumab. The caplacizumab label: “Avoid concomitant use of CABLIVI with antiplatelet agents, thrombolytic drugs, heparin, or anticoagulants.”
Check it at the source: the caplacizumab FDA label on DailyMed (effective April 24, 2026); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the caplacizumab label say about heparin?
Caplacizumab label, drug interactionsMonitor closely for bleeding with concomitant use. ( 7 ) Concomitant Use of Anticoagulants, Thrombolytic Drugs, Heparin or Antiplatelet Agents Concomitant use of CABLIVI with any anticoagulant, thrombolytic drugs, heparin or antiplatelet agent may increase the risk of bleeding.
Caplacizumab label, warnings and precautionsAvoid concomitant use of CABLIVI with antiplatelet agents, thrombolytic drugs, heparin, or anticoagulants.
Source: FDA drug label (Cablivi), Genzyme Corporation, effective April 24, 2026 (SPL set 2348f06e-8004-4040-832e-e9e86a39f905), via openFDA; the full label on DailyMed
What does the heparin label say about caplacizumab?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name caplacizumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caplacizumab | Heparin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once