What the FDA labels say about taking them together
Cannabidiol and sirolimus
Cannabidiol's FDA label of May 29, 2026 names sirolimus in its drug interactions section, and sirolimus's label names cannabidiol too. The cannabidiol label: “Increases in exposure of other orally administered P‑gp substrates may be observed when concomitantly used with EPIDIOLEX.”
Check it at the source: the cannabidiol FDA label on DailyMed (effective May 29, 2026, Jazz Pharmaceuticals, Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the cannabidiol label say about sirolimus?
Cannabidiol label, drug interactionsIncreases in exposure of other orally administered P‑gp substrates (e.g., sirolimus, tacrolimus, digoxin) may be observed when concomitantly used with EPIDIOLEX.
Source: FDA drug label (Epidiolex), Jazz Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 8bf27097-4870-43fb-94f0-f3d0871d1eec), via openFDA; the full label on DailyMed
What does the sirolimus label say about cannabidiol?
Sirolimus label, drug interactionsSe Therapeutic drug monitoring and dose reduction for sirolimus should be considered when sirolimus is co-administered with cannabidiol ( 5.21 , 7.5 ).
Sirolimus label, warnings and precautionsWhen cannabidiol and sirolimus are co-administered, closely monitor for an increase in sirolimus blood levels and for adverse reactions suggestive of sirolimus toxicity.
Source: FDA drug label (Sirolimus, NDA021110), Mylan Pharmaceuticals Inc., effective March 26, 2026 (SPL set 5908cd1a-fc5a-462f-99ed-1d8983e253c9), via openFDA
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cannabidiol | Sirolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once