What the FDA labels say about taking them together
Cannabidiol and divalproex
Divalproex's FDA label of March 31, 2026 names cannabidiol in its drug interactions section; cannabidiol's label does not name divalproex itself but warns about its class (Anti-seizure medicines).
Check it at the source: the cannabidiol FDA label on DailyMed (effective May 29, 2026, Jazz Pharmaceuticals, Inc.); the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.).
What does the cannabidiol label say about divalproex?
Cannabidiol's label does not name divalproex itself; it warns about its class (Anti-seizure medicines):
Cannabidiol label, warnings and precautionsBehavior and Ideation Antiepileptic drugs (AEDs), including EPIDIOLEX, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Cannabidiol label, warnings and precautionsPatients treated with an AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior.
Source: FDA drug label (Epidiolex), Jazz Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 8bf27097-4870-43fb-94f0-f3d0871d1eec), via openFDA; the full label on DailyMed
What does the divalproex label say about cannabidiol?
Divalproex label, drug interactionsHyperammonemia and encephalopathy ( 5.10 , 7.3 ) Cannabidiol: ALT and/or AST elevation
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cannabidiol | Divalproex | |
|---|---|---|
| Labeled for | n/a | Bipolar disorder, Migraine, Seizures and epilepsy |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.194 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once