What the FDA labels say about taking them together
Candesartan/hydrochlorothiazide and methotrexate
Candesartan/hydrochlorothiazide's FDA label of December 22, 2025 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name candesartan/hydrochlorothiazide. The candesartan/hydrochlorothiazide label: “Cytotoxic products – Thiazides may reduce the renal excretion of cytotoxic medicinal products and potentiate their myelosuppressive effects.”
Check it at the source: the candesartan/hydrochlorothiazide FDA label on DailyMed (effective December 22, 2025, ANI Pharmaceuticals, Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the candesartan/hydrochlorothiazide label say about methotrexate?
Candesartan/hydrochlorothiazide label, drug interactionsCytotoxic products – Thiazides may reduce the renal excretion of cytotoxic medicinal products (e.g. cyclophosphamide, methotrexate) and potentiate their myelosuppressive effects.
Source: FDA drug label (Candesartan Cilexetil and Hydrochlorothiazide), NDA021093 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective December 22, 2025 (SPL set bd8d318d-167a-4b26-935d-265dde3193de), via openFDA; the full label on DailyMed
What does the methotrexate label say about candesartan/hydrochlorothiazide?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name candesartan/hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Candesartan/hydrochlorothiazide | Methotrexate | |
|---|---|---|
| Labeled for | High blood pressure | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.954 per tablet 16-12.5 mg tablet | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once