What the FDA labels say about taking them together
Candesartan/hydrochlorothiazide and diazoxide
Candesartan/hydrochlorothiazide's FDA label of December 22, 2025 names diazoxide in its drug interactions section; diazoxide's label does not name candesartan/hydrochlorothiazide itself but warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics).
Check it at the source: the candesartan/hydrochlorothiazide FDA label on DailyMed (effective December 22, 2025, ANI Pharmaceuticals, Inc.); the diazoxide FDA label on DailyMed (effective March 26, 2025, Soleno Therapeutics, Inc.).
What does the candesartan/hydrochlorothiazide label say about diazoxide?
Candesartan/hydrochlorothiazide label, drug interactionsDiazoxide − the hyperglycemic effect of diazoxide may be enhanced by thiazides.
Source: FDA drug label (Candesartan Cilexetil and Hydrochlorothiazide), NDA021093 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective December 22, 2025 (SPL set bd8d318d-167a-4b26-935d-265dde3193de), via openFDA; the full label on DailyMed
What does the diazoxide label say about candesartan/hydrochlorothiazide?
Diazoxide's label does not name candesartan/hydrochlorothiazide itself; it warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics):
Diazoxide label, contraindicationsCONTRAINDICATIONS VYKAT XR is contraindicated in patients with known hypersensitivity to diazoxide, other components of VYKAT XR, or to thiazides.
Diazoxide label, contraindicationsFunctional hypoglycemia Hypersensitivity to diazoxide, any of the excipients in PROGLYCEM, or other thiazides
Source: FDA drug label (VYKAT XR), Soleno Therapeutics, Inc., effective March 26, 2025 (SPL set 0e745e85-9512-e360-e063-6394a90aebf1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Candesartan/hydrochlorothiazide | Diazoxide | |
|---|---|---|
| Labeled for | High blood pressure | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.954 per tablet 16-12.5 mg tablet | $7.38 per mL 50 mg/mL oral suspension |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once