What the FDA labels say about taking them together
Candesartan/hydrochlorothiazide and cyclosporine
Candesartan/hydrochlorothiazide's FDA label of December 22, 2025 names cyclosporine in its drug interactions section; cyclosporine's label does not name candesartan/hydrochlorothiazide itself but warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics). The candesartan/hydrochlorothiazide label: “Cyclosporine − Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.”
Check it at the source: the candesartan/hydrochlorothiazide FDA label on DailyMed (effective December 22, 2025, ANI Pharmaceuticals, Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the candesartan/hydrochlorothiazide label say about cyclosporine?
Candesartan/hydrochlorothiazide label, drug interactionsCyclosporine − Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.
Source: FDA drug label (Candesartan Cilexetil and Hydrochlorothiazide), NDA021093 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective December 22, 2025 (SPL set bd8d318d-167a-4b26-935d-265dde3193de), via openFDA; the full label on DailyMed
What does the cyclosporine label say about candesartan/hydrochlorothiazide?
Cyclosporine's label does not name candesartan/hydrochlorothiazide itself; it warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics):
Cyclosporine label, drug interactionsCaution is also required when cyclosporine is coadministered with potassium sparing drugs (e.g., angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists), potassium-containing drugs as well as in patients on a potassium rich diet.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Candesartan/hydrochlorothiazide | Cyclosporine | |
|---|---|---|
| Labeled for | High blood pressure | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.954 per tablet 16-12.5 mg tablet | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once