Candesartan and Lithium Interaction
Drug interaction information between Candesartan and Lithium.
Candesartan and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Candesartan and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Candesartan can make it harder for your body to get rid of lithium, which can cause the drug to reach toxic levels.
FDA Label Information
7 DRUG INTERACTIONS · Lithium: Increases in serum lithium concentrations and toxicity (7). 7.2 Lithium Increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists, including candesartan cilexetil. Monitor serum lithium levels.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Candesartan + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Candesartan's 2. In the minor band specifically: Candesartan has 1; Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Celecoxib).
What mechanism field is on file for Candesartan and Lithium?
Candesartan can make it harder for your body to get rid of lithium, which can cause the drug to reach toxic levels.
Lithium carries more major-labeled pairs than Candesartan
SPL source-record counts only. This page's band is minor · classes on file: Candesartan (Angiotensin II Receptor Blocker (ARB)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Candesartan's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 1 minor · 2 total
Candesartan has no other minor-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Celecoxib
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.