Candesartan and Aliskiren Interaction
Drug interaction information between Candesartan and Aliskiren.
Candesartan and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Candesartan and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work on the same system to lower blood pressure, which can lead to severe kidney problems and high potassium levels. This double-blocking effect makes side effects much more likely than taking just one drug.
FDA Label Information
7.4 Combination Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with candesartan cilexetil in patients with diabetes. Avoid use of aliskiren with candesartan cilexetil in patients with renal impairment (GFR <60 ml/min) [see Contraindications (4)].
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Enalapril major
Frequently Asked Questions
What SPL severity band is on file for Candesartan + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Candesartan's 2. In the major band specifically: Candesartan has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Candesartan and Aliskiren?
Both drugs work on the same system to lower blood pressure, which can lead to severe kidney problems and high potassium levels. This double-blocking effect makes side effects much more likely than taking just one drug.
Aliskiren carries more major-labeled pairs than Candesartan
SPL source-record counts only. This page's band is major · classes on file: Candesartan (Angiotensin II Receptor Blocker (ARB)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Candesartan's 1.
1 major · 0 moderate · 1 minor · 2 total
Candesartan has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.