What the FDA labels say about taking them together
Calcium gluconate and ceftriaxone
Calcium gluconate's FDA label of May 6, 2024 names ceftriaxone in its contraindications section; the ceftriaxone labels PlainMeds reads (2) do not name calcium gluconate. The calcium gluconate label: “CONTRAINDICATIONS Calcium Gluconate in Sodium Chloride Injection is contraindicated in: Hypercalcemia Neonates receiving ceftriaxone Hypercalcemia Neonates receiving ceftriaxone”
Check it at the source: the calcium gluconate FDA label on DailyMed (effective May 6, 2024, Fresenius Kabi USA, LLC); the ceftriaxone FDA label on DailyMed (effective February 4, 2026, Qilu Pharmaceutical Co., Ltd.).
What does the calcium gluconate label say about ceftriaxone?
Calcium gluconate label, contraindicationsCONTRAINDICATIONS Calcium Gluconate in Sodium Chloride Injection is contraindicated in: Hypercalcemia Neonates (28 days of age or younger) receiving ceftriaxone [see Warnings and Precautions ( 5.2 )] Hypercalcemia ( 4 ) Neonates (28 days of age or younger) receiving ceftriaxone
Calcium gluconate label, warnings and precautionsConcurrent use of intravenous ceftriaxone may cause life-threatening precipitates.
Calcium Gluconate In Sodium Chloride label (WG Critical Care, LLC, June 30, 2026), contraindicationsNeonates (28 days of age or younger) receiving ceftriaxone [see Warnings and Precautions ( 5.2 )]
Calcium Gluconate In Sodium Chloride label (WG Critical Care, LLC, June 30, 2026), warnings and precautionsEnd-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Concurrent use of intravenous ceftriaxone may cause life-threatening precipitates.
Source: FDA drug label (Calcium Gluconate In Sodium Chloride, NDA210906), WG Critical Care, LLC, effective June 30, 2026 (SPL set e6d531ec-fcdc-49f6-b0c4-878d3952827f), via openFDA
Source: FDA drug label (Calcium Gluconate), Fresenius Kabi USA, LLC, effective May 6, 2024 (SPL set 7f5101e0-abf9-4fcf-8986-c799e3333434), via openFDA; the full label on DailyMed
What does the ceftriaxone label say about calcium gluconate?
Ceftriaxone's label (effective February 4, 2026) and its 1 other brand-application label do not name calcium gluconate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ceftriaxone Sodium), Qilu Pharmaceutical Co., Ltd., effective February 4, 2026 (SPL set 4cdf0743-c62b-4969-b9c9-4c6400644f6c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium gluconate | Ceftriaxone | |
|---|---|---|
| Labeled for | n/a | Urinary tract infections, Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.44 per vial 1 g vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once