What the FDA labels say about taking them together
Calcium chloride, magnesium chloride, potassium chloride and sodium chloride and sodium bicarbonate
Calcium chloride, magnesium chloride, potassium chloride and sodium chloride's FDA label of May 27, 2026 names sodium bicarbonate in its contraindications section; the sodium bicarbonate labels PlainMeds reads (3) do not name calcium chloride, magnesium chloride, potassium chloride and sodium chloride.
Check it at the source: the calcium chloride, magnesium chloride, potassium chloride and sodium chloride FDA label on DailyMed (effective May 27, 2026, Hospira, Inc.); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the calcium chloride, magnesium chloride, potassium chloride and sodium chloride label say about sodium bicarbonate?
Calcium chloride, magnesium chloride, potassium chloride and sodium chloride label, contraindicationsCONTRAINDICATIONS Plegisol must not be administered without the addition of 8.4% Sodium Bicarbonate Injection, USP, Hospira List 4900.
Calcium chloride, magnesium chloride, potassium chloride and sodium chloride label, warningsThe buffered solution with added sodium bicarbonate should be cooled to 4°C prior to administration and used within 24 hours of mixing.
Source: FDA drug label (Plegisol), Hospira, Inc., effective May 27, 2026 (SPL set 35a174f0-f0d7-4ec7-3f81-d3d572c059cf), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about calcium chloride, magnesium chloride, potassium chloride and sodium chloride?
Sodium bicarbonate's label (effective August 4, 2026) and its 2 other brand-application labels do not name calcium chloride, magnesium chloride, potassium chloride and sodium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium chloride, magnesium chloride, potassium chloride and sodium chloride | Sodium bicarbonate | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.154 per mL 8.4% vial |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once