What the FDA labels say about taking them together
Calcium carbonate and rilpivirine
Rilpivirine's FDA label of August 28, 2025 names calcium carbonate in its drug interactions section; the calcium carbonate label PlainMeds reads does not name rilpivirine. The rilpivirine label: “The combination of EDURANT or EDURANT PED and antacids should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). …”
Check it at the source: the calcium carbonate FDA label on DailyMed (effective December 5, 2024); the rilpivirine FDA label on DailyMed (effective August 28, 2025, Janssen Products, LP).
What does the calcium carbonate label say about rilpivirine?
Calcium carbonate's label (effective December 5, 2024) does not name rilpivirine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TUMS EX), Haleon US Holdings LLC, effective December 5, 2024 (SPL set 593a0494-d669-4bcf-8412-b92645b2d76c), via openFDA; the full label on DailyMed
What does the rilpivirine label say about calcium carbonate?
Rilpivirine label, drug interactionsConcomitant Drug Class/Drug Name: Antacids: antacids (e.g., aluminum or magnesium hydroxide, calcium carbonate); Effect on Concentration of Rilpivirine or Concomitant Drug: ↔ rilpivirine (antacids taken at least 2 hours before or at least 4 hours after rilpivirine); Clinical Comment: The combination of EDURANT or EDURANT PED and antacids should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in gastric pH). Antacids should only be administered either at least 2 hours before or at least 4 hours after EDURANT or EDURANT PED.
Source: FDA drug label (EDURANT), Janssen Products, LP, effective August 28, 2025 (SPL set 03880372-2c68-45c6-a53a-f420c49541d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium carbonate | Rilpivirine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0315 per tablet 750 mg tablet chewable | $48.04 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once